A simple and sensitive spectrophotometric method has been developed for simultaneous determination of Meropenem and Sulbactam in a binary mixture. In the proposed method, the absorbances were measured at 296.0 nm and 258.0 nm corresponding to the absorbance maxima of Meropenem and Sulbactam in 0.05 N Sodium Hydroxide respectively. Linearity range was observed in the concentration range of 5-25 μg/ml for Meropenem and 2.5-12.5 μg/ml for Sulbactam. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 296.0 nm and 258.0 nm and solving the simultaneous equation. Developed method was applied to laboratory mixture. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and precise.
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